U.S. stock index futures surged after the Federal Reserve raised interest rates and reaffirmed its focus on controlling inflation, easing a major source of market uncertainty. At 4:45 a.m. ET, Dow E-minis were up 340 points, or 0.66%, S&P 500 E-minis had risen 56.25 points, or 0.74%, and Nasdaq 100 E-minis had gained 277.75 points, or 0.96%. Alphabet and Meta each climbed more than 1% before the bell, while CoreWeave, Nebius and IREN rose 6%, 9% and 5%, respectively. Fluence Energy fell 18% after cutting its fiscal 2026 revenue forecast. The central bank indicated that additional rate increases may be needed to curb price pressures, lifting the perceived probability of an October hike to 51% from nearly 44% a day earlier, according to the CME FedWatch tool. The benchmark S&P 500 had fallen 1.7% so far in September, traditionally a weak month for equities. The 10-year U.S. Treasury yield slipped, reducing some pressure on stocks, while Brent crude fell more than 1% to $104.43 and West Texas Intermediate declined 1% to $101.35. Chris Zaccarelli, chief investment officer at Northlight Asset Management, said inflation had remained above target for more than five years and that Fed Chair Kevin Warsh had handled the policy challenge well. He also said the Federal Reserve typically raises rates multiple times after beginning a tightening cycle, although the timing between meetings is less predictable.