Xenon Pharmaceuticals shares sank 25% after the company paused enrollment of new patients in clinical studies for treatments for major and bipolar depression, citing neuropsychiatric side effects. The pause is expected to be temporary. Steel Dynamics and Nucor each fell more than 1.5% after issuing third-quarter earnings guidance that was weaker than FactSet consensus estimates. Nucor said earnings in its steel mills and steel products segments are expected to increase, while raw materials earnings are expected to decrease. Netflix declined more than 3% after Wells Fargo downgraded the stock to underweight, citing concerning engagement trends and weaker content expected in the second half of 2026. Shares of crypto-exposed companies rose after bitcoin crossed $78,000 again, gaining 2%; Robinhood rose 2.5%, Coinbase added 1% and Strategy jumped 3%. Macom Technology Solutions gained 3% after BMO Capital Markets upgraded the stock to outperform, saying its valuation had become attractive after a more than 35% decline from its 2026 highs while fundamentals remained strong in its data center, industrial and defense businesses.