U.S. equity futures traded lower Tuesday morning as Brent crude held above $98 per barrel and approached $100, strengthening expectations that the Federal Reserve could pursue further interest-rate increases at its upcoming policy meeting. Semiconductor stocks tied to artificial intelligence bucked the broader weakness, with Intel rising 3.6% in premarket trading and AMD, Marvell, Micron and Sandisk also gaining. ASML climbed 2% after Samsung, Taiwan Semiconductor Manufacturing and Intel confirmed plans to adopt its High-NA extreme ultraviolet lithography systems. The company’s Chief Technology Officer said a shift from 6-inch to 12-inch photomasks could increase machine productivity by as much as 40%; TSMC and ASML are targeting a 12-inch mask-testing facility by 2031 and commercial production by 2033. Roivant Sciences surged 20% after subsidiary Pulmovant reported positive Phase 2 data for mosliciguat, which reduced pulmonary vascular resistance by approximately 56% versus placebo, increased six-minute walking distance by roughly 35 meters and lowered a cardiac stress biomarker by 53%. Novartis fell 13% after del-desiran missed the primary endpoint in the Phase 3 HARBOR study for myotonic dystrophy type 1, while Dyne Therapeutics, Sarepta Therapeutics, NewAmsterdam Pharma and Amgen also declined. Novartis’s Chief Medical Officer described setbacks as part of drug development, and the company maintained its forecast for 5% to 6% annual revenue growth through 2030. Zim Integrated Shipping Services gained 6% after Hapag-Lloyd and FIMI said they would revise their proposed $4.2 billion takeover following consultations with Israeli authorities. Bloom Energy, Everpure and Illumina also rose ahead of their scheduled S&P 500 inclusion on September 21, while Builders FirstSource, Molson Coors Beverage and Trade Desk fell amid plans for their removal.