U.S. stocks traded lower Thursday, with the Dow Jones Industrial Average down about 350 points, or 0.70%, to 51,153.35. The NASDAQ also fell 0.70% to 26,746.39, while the S&P 500 declined 0.46% to 7,670.50. Energy shares gained 1.7%, leading sectors, while materials stocks fell 1.1%. Darden Restaurants missed analyst expectations for both first-quarter earnings and sales. Apimeds Pharmaceuticals US surged 163% after its subsidiary MindWave signed a 12-month technology services agreement with AQUAE Holdings to deploy MindChain as the foundation of AQUAEChain. Surrozen jumped 90% after submitting an IND application for SZN-8141 to treat diabetic macular edema, while Everpure rose 18% after outlining a broader growth strategy and issuing a preliminary fiscal 2028 outlook. Stitch Fix fell 22% after mixed fourth-quarter results and weak fiscal 2027 sales guidance, while ACADIA Pharmaceuticals and Viking Therapeutics declined after clinical-trial disclosures and proposed public offerings, respectively. Oil rose 4.4% to $96.25, while gold and silver fell. European shares were mixed and Asian markets mostly declined. U.S. economic data showed a wider second-quarter current account deficit, lower initial jobless claims and a smaller-than-expected decline in August building permits.