Major U.S. stock indexes finished mostly lower Thursday as retail traders focused on sharp moves in Apimeds Pharmaceuticals, Everpure and Akamai, alongside Meta and Costco. The Dow Jones Industrial Average fell 0.31% to 51,349.98, the S&P 500 slipped 0.02% to 7,703.13 and the Nasdaq gained 0.01% to 26,939.37. Apimeds surged 114.85% to $4.92 after its subsidiary MindWave Innovations signed a 12-month agreement with Singapore-based AQUAE Holdings to develop, deploy and operate AQUAEChain, a blockchain platform for trading insured ecosystem-conservation credits. Everpure rose 11.15% to $121.88 after reaffirming fiscal 2027 guidance and introducing fiscal 2028 targets. Akamai fell 6.78% during regular trading but jumped 20.65% after hours after expanding its Anthropic agreement to $11.6 billion in contractual commitments over seven years. Meta gained 4.5% on investor interest in its Muse AI strategy, while Costco slipped 0.91% despite quarterly revenue and earnings exceeding analyst estimates. Benzinga Edge Stock Rankings placed Meta's Momentum score in the 82nd percentile and its Value score in the 46th percentile.