U.S. stocks ended higher on Wednesday, breaking a three-day losing streak, while U.S. equity futures rose 0.3% on Friday as investors assessed inflation, energy-price, bond-yield and deficit risks. The iShares Genomics Immunology and Healthcare ETF (IDNA) surged 13.53% in one day, driven by positive Phase 3 trial results from Moderna and Merck. This jump came with 2.8 times average trading volume, reflecting strong investor interest. Hong Kong shares also advanced, led by biotech and gold-related stocks after Moderna's personalized mRNA cancer vaccine met key Phase III trial endpoints. Technology shares, chipmakers, AI hyperscalers and Walmart remained under pressure after steep weekly losses and a rare earnings miss, highlighting continued concern about valuations, corporate debt issuance and the U.S. consumer.