Texas Democratic Senate candidate James Talarico and billionaire investor Mark Cuban have announced a joint "Breaking up Big Medicine" plan that backs antitrust legislation targeting healthcare monopolies, seeks to lower prescription-drug prices and aims to address medical debt and insurance costs. The plan specifically targets the 16.7% of Texans who are uninsured, according to their press release. Talarico and Cuban are scheduled to appear Saturday evening in Fort Worth for a live podcast event focused on healthcare monopolies. Talarico, a member of the Texas House of Representatives, is running against Texas Attorney General Ken Paxton in a closely watched 2026 Senate race. Recent polls suggest Talarico is leading, while Paxton has the endorsement of President Trump, who visited Texas earlier this week for a Republican National Convention fundraising event. Talarico's proposal would target vertically integrated healthcare conglomerates, including pharmacy benefit managers, insurers and hospital networks; bar pharmacy benefit managers from concealing pricing data; encourage generic-drug development and approval; and cap out-of-pocket costs. Talarico has said large hospital systems control 90% of hospital beds and that CVS Caremark, Cigna's Express Scripts and UnitedHealth Group's Optum Rx process roughly 80% of prescriptions nationwide. Cuban's support is consistent with the mission of his Mark Cuban Cost Plus Drug Company, founded in 2022 to reduce medicine prices by cutting out pharmaceutical intermediaries and negotiating directly with manufacturers. The partnership comes as other Democratic candidates weigh how closely to associate with former Vice President Kamala Harris, whose support has become more politically complicated after her 2024 election loss. Iowa state Rep. Josh Turek said he did not want Harris to campaign for him, while former Rep. Mary Peltola's Senate campaign pushed aside a Harris fundraising email. During the Fort Worth event, Trump is scheduled to meet with his super PAC, MAGA Inc., at his National Golf Club outside Washington, D.C.; Politico reported that the committee may hold more than $400 million for Republican candidates ahead of the November midterms.