HUTCHMED licenses HMPL-A830 to GSK for up to $1.295 billion

  • HUTCHMED granted GSK exclusive rights to develop and commercialize HMPL-A830 outside Mainland China, Hong Kong, Macau and Taiwan.
  • The deal provides US$110 million upfront and up to US$1.185 billion in additional milestones, for potential consideration of US$1.295 billion plus tiered royalties.
  • Daiwa upgraded HUTCHMED to Buy with an $18.50 price target, while global Phase I development is expected to begin in the second half of 2026.

HUTCHMED shares surged 17.77% after the company announced an exclusive licensing agreement with GSK worth up to $1.295 billion, while Daiwa upgraded the company to Buy and set an $18.50 price target. The agreement gives GSK rights to develop and commercialize HMPL-A830 worldwide outside Mainland China, Hong Kong, Macau and Taiwan. HUTCHMED will receive $110 million upfront, up to $1.185 billion in development, regulatory and commercial milestones, and tiered royalties. HMPL-A830 is a first-in-class antibody-targeted therapy conjugate combining a KRAS inhibitor payload with an EGFR antibody. HUTCHMED will lead global Phase I development, expected to begin in the second half of 2026, before GSK assumes later development and commercialization outside the reserved markets.

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