ResearchAndMarkets adds selinexor, pelabresib and REBLOZYL forecasts through 2034

  • ResearchAndMarkets.com added separate reports forecasting selinexor, pelabresib and REBLOZYL sales and market size through 2034 across the 7MM.
  • MANIFEST-2 showed a 35% or greater spleen-volume reduction in 65.9% of patients receiving pelabresib plus ruxolitinib, versus 35.2% with placebo plus ruxolitinib.
  • REBLOZYL’s COMMANDS trial recorded the required transfusion-independence and hemoglobin response in 58.5% of patients, versus 31.2% with epoetin alfa, while selinexor and pelabresib myelofibrosis uses remain subject to regulatory decisions.

ResearchAndMarkets.com added separate reports forecasting sales and market size through 2034 for selinexor, pelabresib and REBLOZYL across the seven major markets (7MM): the United States, Germany, France, Italy, Spain, the United Kingdom and Japan. Selinexor is marketed as XPOVIO for multiple myeloma and relapsed or refractory diffuse large B-cell lymphoma, while its potential myelofibrosis use is supported by Phase III SENTRY data showing a statistically significant spleen-volume-reduction result but not a statistically significant total-symptom-score result. Pelabresib remains investigational; in Phase III MANIFEST-2, 65.9% of patients receiving pelabresib plus ruxolitinib achieved at least a 35% spleen-volume reduction at Week 24, versus 35.2% with placebo plus ruxolitinib, while the overall total symptom score endpoint was not statistically significant. REBLOZYL is approved for beta-thalassemia and myelodysplastic syndromes, with potential opportunities in myelofibrosis and alpha-thalassemia; in COMMANDS, 58.5% of patients achieved at least 12 weeks of red blood cell transfusion independence with a hemoglobin increase of at least 1.5 g/dL, compared with 31.2% for epoetin alfa. The reports assess clinical development, regulatory milestones, pricing, reimbursement, patents, generic-entry risks, competition and commercial scenarios.

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