Natural Grocers® will open its second Wisconsin store in Appleton on September 30, 2026, at 720 N. Casaloma Drive, serving Appleton, Fox Crossing, Kaukauna, Neenah and surrounding communities. The grand opening will include giveaways, mystery gift cards, a hand-crafted Ecuadorian backpack for early shoppers, a prize wheel, samples, radio programming and sweepstakes. The good4u® Crew will present $2,500 to Feeding America Eastern Wisconsin at 8:15 a.m., followed by a ribbon-cutting with the Fox City Chamber and store leadership; doors will open at 8:27 a.m. Opening promotions will include discounts of up to 50% through October 31 and exclusive pricing for members of the free {N}power rewards program. The store will feature organic and natural groceries, a supplement department, nutrition education, sustainable building upgrades and a planned onsite Nutritional Health Coach.