The Nasdaq 100 reached a fresh intraday record by midday Tuesday, rising 0.41% to 30,607.20 as artificial-intelligence shares extended their gains. The S&P 500 was nearly unchanged at 7,761.28, while the Dow Jones Industrial Average fell 263 points, or 0.51%, to 51,785.94. Banks led declines after the 10-year Treasury yield rose 2 basis points to 4.98%, with JPMorgan Chase, Wells Fargo and Morgan Stanley all lower. Viking Therapeutics surged 30.7% after its VK2735 study showed that less frequent dosing preserved most of the weight loss achieved with weekly treatment; the company plans to begin Phase 3 trials by year-end. Vicor, On Holding, Monolithic Power Systems and other AI-related hardware stocks also advanced. West Texas Intermediate crude fell 0.6% to $91.81 a barrel for its fifth straight daily decline, while President Donald Trump said he faces a "big decision" over negotiations with Tehran or whether to "annihilate the Islamic Republic."