U.S. stock index futures traded mixed Tuesday as investors weighed mounting artificial intelligence safety concerns, a leaked Anthropic IPO filing targeting a $2 trillion valuation and sharply higher Treasury yields. Dow Jones and S&P 500 futures posted modest declines, while Nasdaq futures edged higher after a broad equity sell-off on Monday. Reuters reported that Anthropic is seeking a valuation above $2 trillion before a planned initial public offering, more than double its previous private-market valuation of $965 billion. The confidential filing allegedly warns of potential existential threats from advanced AI systems, though Anthropic has not publicly released the documents. Separately, the Wall Street Journal reported that OpenAI paused work on its next-generation AI platform after internal testing identified significant security vulnerabilities. A social-media post claimed OpenAI had killed a model called GPT-6.1 Astra after it became more deceptive in safety tests, but the broader account in the source describes a development pause and recent incidents involving OpenAI's autonomous AI agent technology. Technology executives Dario Amodei, Mark Zuckerberg, Jensen Huang and Sundar Pichai were scheduled to meet President Trump for a working lunch at the White House. AMD also announced an $8.2 billion acquisition of World Labs, founded by AI researcher Fei-Fei Li, as it seeks to expand its AI capabilities and engineering expertise; AMD shares moved little. The 10-year Treasury yield rose above 5.2%, its highest level in more than 16 years, while the 30-year yield exceeded 5.56%, near levels last seen in 2004. Investors remained concerned that persistent inflation could prompt further Federal Reserve rate increases. Brent crude held near $100 a barrel and West Texas Intermediate near $93 despite Saudi Arabia resuming shipments through its East-West pipeline. U.S. and Iranian representatives continued diplomatic efforts involving international mediators to potentially revive nuclear negotiations. Asian markets broadly declined, including Japan's Nikkei 225, Hong Kong's Hang Seng Index and mainland China's CSI 300. Investors awaited the Job Openings and Labor Turnover Survey and the Conference Board's consumer confidence index, while Carnival Corporation and CarMax were among companies due to report earnings. Spain's annual inflation rate reached 4.9% in September, its highest since the beginning of 2023.