The U.S. April ISM (Institute for Supply Management) Manufacturing PMI (Purchasing Managers’ Index, a factory activity gauge) was 52.7, matching the previous reading of 52.7 and falling short of the 53.1 estimate in the source. A reading above 50 generally signals expansion in manufacturing activity, so the data points to continued growth in the sector, but the miss versus expectations suggests momentum was weaker than analysts had projected. For crypto markets, major U.S. macroeconomic releases are closely watched because they can influence interest-rate expectations, risk appetite, and liquidity conditions across Bitcoin and other digital assets.